Copy Number Variations in DISC1 and DISC1-Interacting Partners in Major Mental Illness
نویسندگان
چکیده
منابع مشابه
Copy Number Variations in DISC1 and DISC1-Interacting Partners in Major Mental Illness
Robust statistical, genetic and functional evidence supports a role for DISC1 in the aetiology of major mental illness. Furthermore, many of its protein-binding partners show evidence for involvement in the pathophysiology of a range of neurodevelopmental and psychiatric disorders. Copy number variants (CNVs) are suspected to play an important causal role in these disorders. In this study, CNV ...
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Schizophrenia and related disorders have a major genetic component, but despite much effort and many claims, few genes have been consistently replicated and fewer have biological support. One recent exception is "Disrupted in Schizophrenia 1" (DISC1), which was identified at the breakpoint on chromosome 1 of the balanced translocation (1;11)(q42.1;q14.3) that co-segregated in a large Scottish f...
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ژورنال
عنوان ژورنال: Molecular Neuropsychiatry
سال: 2015
ISSN: 2296-9209,2296-9179
DOI: 10.1159/000438788